A inherited connective tissue disorder that involves a mutation in the gene that makes fibrillin. It most commonly affects the heart, eyes, blood vessels and skeleton. Signs and symptoms range from mild to severe and can include but are not limited to: heart murmurs, extreme nearsightedness, abnormally curved spine (scoliosis), flat feet, a breastbone the protrudes outward or dips inward, disproportionately long arms, legs and fingers, and a tall/slender build.