For more on MCAS, secondary to EDS: https://onlinelibrary.wiley.com/doi/full/10.1002/ajmg.c.31555 Skin: Recurrent Flushing, Itching, Swelling, Hives, Dermatitis (eczema), increased/decreased sweating Gastrointestinal: Episodic pain, urgency, Irritable Bowel Syndrome (IBS), GERD, Eosinophilic Esophagitis (EoE), constipation, gastroparesis, increasing food allergies/sensitivities, gallbladder issues Cardiovascular, Respiratory, and/or Neuropsychiatric: Dysautonomia (Postural Orthostatic Tachycardia Syndrome (POTS); resting tachycardia; breathing problems) Anaphylaxis, Rhinitis (Hay Fever), Anxiety, Depression.