The blockage of cerebrospinal fluid, such as that associated with a Chiari malformation, is what causes a syrinx. Certain comorbidities, such as Spinal Stenosis, can also be pathological to a syrinx. A syrinx can happen anywhere in the spine and/or brainstem. When a syrinx forms in or reaches up to the brainstem, it is known as Syringobulbia (which will be tomorrow’s fact). The severity of the syrinx is based on its size in diameter and location of the spine.
For more information on Syringomyelia: